Scientists have found that CoQ10 supplements are potentially beneficial to people living with heart disease. In a long-term study, people living with moderate to severe heart failure who took daily CoQ10 supplements had a reduced risk — specifically 42% — of having their first major adverse cardiovascular event (MACE).

Statin medication user, heart disease, nutrient deficiencies, genetic mutations, oxidative stress and cancer also need CoQ10.

Statins are a group of medications that are used to lower high blood levels of cholesterol or triglycerides to prevent heart disease。

Though these drugs are generally well tolerated, they can cause adverse side effects, such as serious muscle injury and liver damage.

Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues 

A study in 50 people taking statin medications found that a dose of 100 mg of CoQ10 per day for 30 days effectively reduced statin-related muscle pain in 75% of patients (11Trusted Source).

However, other studies have shown no effect, emphasizing the need for more research on this topic.

For people taking statin medications, the typical dosage recommendation for CoQ10 is 30–200 mg per day.

 

Those with heart conditions, such as heart failure and angina, may benefit from taking a CoQ10 supplement.

A review of 13 studies in people with heart failure found that 100 mg of CoQ10 per day for 12 weeks improved blood flow from the heart.

Plus, supplementing has been shown to reduce the number of hospital visits and the risk of dying from heart-related issues in individuals with heart failure.

CoQ10 is also effective in reducing the pain associated with angina, which is chest pain caused by your heart muscle not getting enough oxygen.

What’s more, the supplement may reduce heart disease risk factors, such as by lowering “bad” LDL cholesterol.

For people with heart failure or angina, the typical dosage recommendation for CoQ10 is 60–300 mg per day.

When used alone or in combination with other nutrients, CoQ10 has been shown to improve migraine symptoms.

It has also been found to ease headaches by reducing oxidative stress and free radical production, which may otherwise trigger migraines.

CoQ10 decreases inflammation in your body and improves mitochondrial function, which helps reduce migraine-associated pain.

A three-month study in 45 women demonstrated that those treated with 400 mg of CoQ10 per day experienced significant reductions in the frequency, severity and duration of migraines, compared to a placebo group .

For treating migraines, the typical dosage recommendation for CoQ10 is 300–400 mg per day.